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KMID : 0986520150150020025
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Korean Journal of Endoscrine Surgery
2015 Volume.15 No. 2 p.25 ~ p.33
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Prognostic Value of p53 and Cyclin D1 in Papillary Thyroid Carcinoma
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Seok Jae-Yeon
Chung Dong-Hae
Chung Yoo-Seung
Ryu Jung-Won
Lee Young-Don
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Abstract
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Purpose: P53 and cyclin D1 have been evaluated as a prognostic marker in papillary thyroid carcinoma (PTC). However, the relationship between p53/cyclin D1 and PTC prognosis has not yet been confirmed. Therefore, we investigated the relationship between p53/cyclin D1 and PTC prognostic factors.
Methods: 919 patients with PTC were enrolled. Immunohistochemistry slides were reviewed for p53 and cyclin D1 immunoreactivity. Patients were classified into two groups according to the p53 and cyclin D1 grade: negative for ≤5% and positive for ＞5%. Medical records were reviewed to evaluate the prognostic factors, lymph node metastatic ratio (LNMR), and MACIS score. We analyzed patients based on p53/cyclin D1(?/?), p53/cyclin D1(?/＋), p53/cyclin D1(＋/?), p53/cyclin D1(＋/＋) separately for evaluation of independent effect of p53 and cyclin D1.
Results: Mean age of the patients was 49.73 years (range 15∼87), and tumor size was 1.19 cm (range 0.1∼5.0). P53 was positive in 809 (88.0%) and cyclin D1 was positive in 748 (81.4%). Positivity of p53 and cyclin D1 were correlated (r=0.448). There was no statistical significance in MACIS score. Positivity of p53 and cyclin D1 were related with larger tumor size, older age, early T stage, more tumor capsulation, and female. LNMR was higher in p53/cyclin D1(＋/?) than p53/cyclin D1(?/?) (P=0.036), p53/cyclin D1(?/＋) than p53/cyclin D1(?/?) (P=0.034), and p53/cyclin D1(＋/＋) than p53/cyclin D1(?/?) (P=0.007).
Conclusion: There was no consistent relationship between p53/cyclin D1 and worse prognostic factors of PTC. However, LNMR was higher in p53(＋) and cyclin D1(＋) cases independently, much more in p53/cyclin D1(＋/＋) than p53/cyclin D1(?/?).
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KEYWORD
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Papillary thyroid carcinoma, p53, Cyclin D1, Prognosis, Lymph node metasta-tic ratio
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